PI: Tim Wang
PI for subcontract: James Fox
Grant Period: 12/7/2016 - 11/30/2023
Funded by: NIH via Columbia University
Title: The Role of Stem Cells and the Microenvironment in Gastrointestinal Cancers
Project Goals: Investigate the role of Helicobacter as a tumor promoter. In this grant a mouse model is used to examine the mechanisms by which Helicobacter infections contribute to the malignant process.
Specific Aims:
- Provide ongoing histopathological support for the in vivo models to be utilized in the specific aims outlined.
- Where needed, provide special immunohistochemistry assays on target tissues, qPCR for tissue cytokines/chemokines, and serologic assessment of biomarkers utilizing the Luminex platform.
PI: Jiahe Li
PI for subcontract: James Fox and Omer Yilmaz
Grant Period: 4/01/2021 – 3/31/2024
Funded by: DOD via Northeastern University
Title: Programming Indigenous Gut Bacteria to Prevent Colorectal Cancer Induced by Microbial Carcinogen
Project Goal: Development of microbial based therapies for intestinal cancers
Specific Aims:
- Use a germ free mouse model to determine the role of the microbiota in esophageal cancer formation
PI: Tim Wang
Grant Period: 12/7/2016 - 11/30/2023
Funded by: NIH via Columbia University
Title: The Role of Stem Cells and the Microenvironment in Gastrointestinal Cancers
Project Goals: Investigate the role of Helicobacter as a tumor promoter. In this grant a mouse model is used to examine the mechanisms by which Helicobacter infections contribute to the malignant process.
Specific Aims:
- Provide ongoing histopathological support for the in vivo models to be utilized in the specific aims outlined.
- Where needed, provide special immunohistochemistry assays on target tissues, qPCR for tissue cytokines/chemokines, and serologic assessment of biomarkers utilizing the Luminex platform.
