Hilda Holcombe, DVM, PhD, DACLAM, is a Senior Research/Clinical Veterinarian with primary responsibilities for rodents in the Koch Institute and non-primate species in E17/18. She received her PhD in immunology following graduation from veterinary school and has a primary interest in mucosal immunity. Her current research focuses on novel approaches for using engineered nucleases to generate genetically modified inbred guinea pigs. She also studies macrophage function in rodent models of IBD.
Robin Kramer, DVM, DACLAM, is Veterinary Coordinator of Research Services, acting as a liaison between DCM and the Committee on Animal Care (CAC). Dr. Kramer also provides clinical support for multiple species. She received her veterinary degree from the University of Missouri and spent 5 years in private practice before completing a post-doctoral fellowship in laboratory animal medicine at the Tri-Institutional Training Program in New York City. In addition to her clinical experience, Dr. Kramer has IACUC (CAC) experience at multiple institutions, most recently with Boston University. Dr. Kramer’s research interests include the tumor microenvironment and investigating spontaneous disease in laboratory animal species. Dr. Kramer is available to assist with protocol writing and review as well as consult on unexpected outcomes due to clinical disease or experimental procedures.
Sureshkumar Muthupalani, BVSc, PhD, DACVP, is the Chief of Comparative Pathology and has more than 10 years of experience as a comparative pathologist within the institution. He is a veterinarian with a PhD in Microbiology from the University of Kentucky and residency training in anatomic pathology from the Tufts Cummings School of Veterinary Medicine. Dr. Muthupalani is responsible for laboratory animal pathology services as well as collaborating with a variety of principal investigators and scientists within and outside of the Division. He provides oversight of DCM’s histology and diagnostic pathology laboratories and is involved in quality control as well as standardization of new immunohistochemistry protocols. His current collaborative research and pathology expertise spans a broad range of animal disease models with more than 56 scientific publications to his credit. In addition, he is involved in the phenotypic characterization of genetically engineered mice as well as spontaneous diseases of laboratory animals.
Mary Patterson, MS, DVM, DACLAM, was in a mixed animal private practice for a number of years prior to entering the DCM postdoctoral training program. Now as a Chief of Primate Ressources, she provides daily oversight for multiple animal species. Much of her time is directed toward the social housing of nonhuman primates, as well as the development of policies and standard operating procedures governing their use. Spontaneous disease and basic research studies, on which she has worked and published have involved rhesus macaques, ferrets, and hamsters. An evolving responsibility is to coordinate for DCM animal containment studies performed at MIT.
Alex Sheh, PhD, is a Research Scientist and is Chief of the Microbiome Core. His research interests include understanding how pathogens and the environment influence the microbiota and consequently, disease outcomes. Dr. Sheh has particular interest in factors that modulate carcinogenesis in H. pylori mouse models and clinical cohorts. Dr. Sheh manages the Division’s metagenomics and bioinformatics pipeline. He is also actively involved in collaborative research on several NIH-funded projects as well as the training and supervision of post-doctoral fellows.